@inbook{9e23a75e6fda49799df3f8db3d00fec4,
title = "Inhibition of UVB-induced nonmelanoma skin cancer: A path from tea to caffeine to exercise to decreased tissue fat",
abstract = "Oral administration of green tea, black tea, or caffeine (but not the decaffeinated teas) inhibited ultraviolet B radiation (UVB)-induced skin carcinogenesis in SKH-1 mice. Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine's inhibition of UVB-induced carcinogenesis. The regular teas or caffeine increased locomotor activity and decreased tissue fat. In these studies, decreased dermal fat thickness was associated with a decrease in the number of tumors per mouse. Administration of caffeine, voluntary exercise, and removal of the parametrial fat pads all stimulated UVB-induced apoptosis, inhibited UVB-induced carcinogenesis, and stimulated apoptosis in UVB-induced tumors. These results suggest that caffeine administration, voluntary exercise, and removal of the parametrial fat pads inhibit UVB-induced carcinogenesis by stimulating UVB-induced apoptosis and by enhancing apoptosis in DNA-damaged precancer cells and in cancer cells. We hypothesize that tissue fat secretes antiapoptotic adipokines that have a tumor promoting effect.",
keywords = "Adipokines, Sunlight-induced skin cancer",
author = "Conney, {Allan H.} and Lou, {You Rong} and Paul Nghiem and Bernard, {Jamie J.} and Wagner, {George C.} and Lu, {Yao Ping}",
note = "Funding Information: Grant Support: Research described in this chapter was supported in part by NIH grants CA 49756, CA 80759, CA 88961, CA 114442, CA 130857, CA 128997, 5T32 ES007148, and AR 49832.",
year = "2013",
doi = "10.1007/128-2012-336",
language = "English (US)",
isbn = "9783642345746",
series = "Topics in Current Chemistry",
pages = "61--72",
editor = "John Pezzuto and Nanjoo Suh",
booktitle = "Natural Products in Cancer Prevention and Therapy",
}