Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents

Yuanli Liu, Xinghan Liu, Yilin Qu, Xiuhong Wang, Liping Li, Xilin Zhao

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2′-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2′-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2′-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.

Original languageEnglish (US)
Pages (from-to)6048-6050
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume56
Issue number11
DOIs
StatePublished - Nov 1 2012

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Thiourea
2,2'-Dipyridyl
Reactive Oxygen Species
Hydroxyl Radical
Daptomycin
Oxacillin
Staphylococcus aureus
Escherichia coli

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Liu, Yuanli ; Liu, Xinghan ; Qu, Yilin ; Wang, Xiuhong ; Li, Liping ; Zhao, Xilin. / Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. In: Antimicrobial agents and chemotherapy. 2012 ; Vol. 56, No. 11. pp. 6048-6050.
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Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. / Liu, Yuanli; Liu, Xinghan; Qu, Yilin; Wang, Xiuhong; Li, Liping; Zhao, Xilin.

In: Antimicrobial agents and chemotherapy, Vol. 56, No. 11, 01.11.2012, p. 6048-6050.

Research output: Contribution to journalArticle

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