Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents

Yuanli Liu, Xinghan Liu, Yilin Qu, Xiuhong Wang, Liping Li, Xilin Zhao

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2′-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2′-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2′-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.

Original languageEnglish (US)
Pages (from-to)6048-6050
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume56
Issue number11
DOIs
StatePublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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