Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture

Yu Shao, Chi Tang Ho, Chee Kok Chin, Vladimir Badmaev, Wei Ma, Mou Tuan Huang

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

Four major triterpene acids including β-boswellic acid (1), 3-O-acetyl- β-boswellic acid (2), 11-keto-β-boswellic acid (3), and 3-O-acetyl-11-keto- β-boswellic acid (4) were isolated from the gum resin of Boswellia serrata and examined for their in vitro antitumor activity. They inhibited the synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 μM. Among them, compound 4 induced the most pronounced inhibitory effects on DNA, RNA and protein synthesis with IC50 values of 0.6, 0.5, and 4.1 μM, respectively. The effect of 4 on DNA synthesis was found to be irreversible. Compound 4 significantly inhibited the cellular growth of HL-60 cells, but did not affect cell viability.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalPlanta Medica
Volume64
Issue number4
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Keywords

  • Antileukemia
  • Boswellia serrata
  • Boswellic acids
  • Burseraceae
  • Cellular growth
  • Macromolecule synthesis
  • Triterpene acids

Fingerprint Dive into the research topics of 'Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture'. Together they form a unique fingerprint.

Cite this