Injection of DNA into plant and animal tissues with micromechanical piercing structures

William Trimmer; Peter Ling; Chee Kok Chin; Portia Orton; Randy Gaugler; Sarwar Hashmi; Ghazala Hashmi; Bruce Brunett; Michael Reed

Injection of DNA into plant and animal tissues with micromechanical piercing structures

William Trimmer, Peter Ling, Chee Kok Chin, Portia Orton, Randy Gaugler, Sarwar Hashmi, Ghazala Hashmi, Bruce Brunett, Michael Reed

Research output: Contribution to conference › Paper › peer-review

30 Scopus citations

Abstract

Silicon micromachining has been used to fabricate microprobes for injecting DNA into cells. Arrays of very sharp pyramidal points are etched on a silicon substrate. Pressing these points into a culture of cells, allows biologically active material to cross the cell wall barrier. Using the microprobes, DNA has been injected into plant (tobacco leaves) and animal (nematodes) cells.

Original language	English (US)
Pages	111-115
Number of pages	5
State	Published - 1995
Externally published	Yes
Event	Proceedings of the 1995 IEEE Micro Electro Mechanical Systems Conference - Amsterdam, Neth Duration: Jan 29 1995 → Feb 2 1995

Other

Other	Proceedings of the 1995 IEEE Micro Electro Mechanical Systems Conference
City	Amsterdam, Neth
Period	1/29/95 → 2/2/95

All Science Journal Classification (ASJC) codes

Control and Systems Engineering
Mechanical Engineering
Electrical and Electronic Engineering

Cite this

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title = "Injection of DNA into plant and animal tissues with micromechanical piercing structures",

abstract = "Silicon micromachining has been used to fabricate microprobes for injecting DNA into cells. Arrays of very sharp pyramidal points are etched on a silicon substrate. Pressing these points into a culture of cells, allows biologically active material to cross the cell wall barrier. Using the microprobes, DNA has been injected into plant (tobacco leaves) and animal (nematodes) cells.",

author = "William Trimmer and Peter Ling and Chin, {Chee Kok} and Portia Orton and Randy Gaugler and Sarwar Hashmi and Ghazala Hashmi and Bruce Brunett and Michael Reed",

year = "1995",

language = "English (US)",

pages = "111--115",

note = "Proceedings of the 1995 IEEE Micro Electro Mechanical Systems Conference ; Conference date: 29-01-1995 Through 02-02-1995",

}

TY - CONF

T1 - Injection of DNA into plant and animal tissues with micromechanical piercing structures

AU - Trimmer, William

AU - Ling, Peter

AU - Chin, Chee Kok

AU - Orton, Portia

AU - Gaugler, Randy

AU - Hashmi, Sarwar

AU - Hashmi, Ghazala

AU - Brunett, Bruce

AU - Reed, Michael

PY - 1995

Y1 - 1995

N2 - Silicon micromachining has been used to fabricate microprobes for injecting DNA into cells. Arrays of very sharp pyramidal points are etched on a silicon substrate. Pressing these points into a culture of cells, allows biologically active material to cross the cell wall barrier. Using the microprobes, DNA has been injected into plant (tobacco leaves) and animal (nematodes) cells.

AB - Silicon micromachining has been used to fabricate microprobes for injecting DNA into cells. Arrays of very sharp pyramidal points are etched on a silicon substrate. Pressing these points into a culture of cells, allows biologically active material to cross the cell wall barrier. Using the microprobes, DNA has been injected into plant (tobacco leaves) and animal (nematodes) cells.

UR - http://www.scopus.com/inward/record.url?scp=0029194598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029194598&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0029194598

SP - 111

EP - 115

T2 - Proceedings of the 1995 IEEE Micro Electro Mechanical Systems Conference

Y2 - 29 January 1995 through 2 February 1995

ER -

Injection of DNA into plant and animal tissues with micromechanical piercing structures

Abstract

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All Science Journal Classification (ASJC) codes

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