Innate Immune Responses to Acinetobacter baumannii in the Airway

Sílvia Pires, Dane Parker

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Acinetobacter baumannii is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of A. baumannii and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Nosocomial pneumonia is the most prevalent of these. This review summarizes the current state of the signaling and innate immune components activated in response to A. baumannii infection in the airway.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalJournal of Interferon and Cytokine Research
Volume39
Issue number8
DOIs
StatePublished - Aug 2019

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

Keywords

  • Acinetobacter baumannii
  • airway
  • host-pathogen
  • innate immunity
  • lung

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