TY - JOUR
T1 - Innate Immune Responses to Acinetobacter baumannii in the Airway
AU - Pires, Sílvia
AU - Parker, Dane
N1 - Publisher Copyright:
© 2019, Mary Ann Liebert, Inc., publishers.
PY - 2019/8
Y1 - 2019/8
N2 - Acinetobacter baumannii is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of A. baumannii and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Nosocomial pneumonia is the most prevalent of these. This review summarizes the current state of the signaling and innate immune components activated in response to A. baumannii infection in the airway.
AB - Acinetobacter baumannii is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of A. baumannii and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Nosocomial pneumonia is the most prevalent of these. This review summarizes the current state of the signaling and innate immune components activated in response to A. baumannii infection in the airway.
KW - Acinetobacter baumannii
KW - airway
KW - host-pathogen
KW - innate immunity
KW - lung
UR - http://www.scopus.com/inward/record.url?scp=85071055387&partnerID=8YFLogxK
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U2 - 10.1089/jir.2019.0008
DO - 10.1089/jir.2019.0008
M3 - Article
C2 - 31013462
AN - SCOPUS:85071055387
VL - 39
SP - 441
EP - 449
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
SN - 1079-9907
IS - 8
ER -