Innate immune signaling activated by MDR bacteria in the airway

Dane Parker, Danielle Ahn, Taylor Cohen, Alice Prince

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Health careassociated bacterial pneumonias due to multiple-drug resistant (MDR) pathogens are an important public health problem and are major causes of morbidity and mortality worldwide. In addition to antimicrobial resistance, these organisms have adapted to the milieu of the human airway and have acquired resistance to the innate immune clearance mechanisms that normally prevent pneumonia. Given the limited efficacy of antibiotics, bacterial clearance from the airway requires an effective immune response. Understanding how specific airway pathogens initiate and regulate innate immune signaling, and whether this response is excessive, leading to host-induced pathology may guide future immunomodulatory therapy. We will focus on three of the most important causes of health care-associated pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae, and review the mechanisms through which an inappropriate or damaging innate immune response is stimulated, as well as describe how airway pathogens cause persistent infection by evading immune activation.

Original languageEnglish (US)
Pages (from-to)19-53
Number of pages35
JournalPhysiological reviews
Volume96
Issue number1
DOIs
StatePublished - Nov 18 2015

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Physiology (medical)

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