Insects: an underrepresented resource for the discovery of biologically active natural products

Lauren Seabrooks, Longqin Hu

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Nature has been the source of life-changing and -saving medications for centuries. Aspirin, penicillin and morphine are prime examples of Nature׳s gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs, moths and more. Biological activities of these natural products from insects include antimicrobial, antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.

Original languageEnglish (US)
Pages (from-to)409-426
Number of pages18
JournalActa Pharmaceutica Sinica B
Volume7
Issue number4
DOIs
StatePublished - Jul 1 2017

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Biological Products
Insects
Isoptera
Gift Giving
Wasps
Cockroaches
Modern 1601-history
Ants
Moths
Bees
Beetles
Drug Discovery
Medicinal Plants
Diptera
Penicillins
Morphine
Aspirin
Antiviral Agents
Anti-Inflammatory Agents
Antioxidants

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Insects : an underrepresented resource for the discovery of biologically active natural products. / Seabrooks, Lauren; Hu, Longqin.

In: Acta Pharmaceutica Sinica B, Vol. 7, No. 4, 01.07.2017, p. 409-426.

Research output: Contribution to journalReview article

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