Insights into DNA helical transmons found in protein-DNA complexes

Andrew V. Colasanti, Yun Li, Gautam Singh, Xiang Jun Lu, Wilma K. Olson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Many proteins essential for the viability of the cell induce large-scale deformations in the DNA double helix. Some of these deformations include transitions of regular B DNA to alternate helical forms, such as A DNA, where base pairs are unwound, displaced, and inclined with respect to the helical axis. Here we examine structural features of the A-like DNA base-pair steps found in a diverse set of high-resolution protein-DNA complexes. The protein-bound DNA is more deformable than the A DNA crystallized in the absence of protein, and the protein microenvironment surrounding A DNA differs in subtle ways from that associated with other types of DNA The kinds of amino-acid atoms in immediate contact with the sugars, phosphates, and bases hint of ways in which small molecules may cluster around A DNA in solution and how changes in solvent may contribute to alterations of helical structure.

Original languageEnglish (US)
Title of host publicationBiomolecular Forms and Functions
Subtitle of host publicationA Celebration of 50 Years of the Ramachandran Map
PublisherWorld Scientific Publishing Co.
Number of pages17
ISBN (Electronic)9789814449144
ISBN (Print)9789814449137
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Insights into DNA helical transmons found in protein-DNA complexes'. Together they form a unique fingerprint.

Cite this