Insights into the Structure and Function of a Chiral Conjugate-Base-Stabilized Brønsted Acid Catalyst

Minami Odagi, Hiroshi Araki, Chang Min, Eri Yamamoto, Thomas J. Emge, Masahiro Yamanaka, Daniel Seidel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A combined experimental and computational study reveals key catalyst-substrate interactions and the main factors controlling stereoselectivity in an asymmetric Pictet–Spengler reaction facilitated by a carboxylic-acid-thiourea catalyst.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number2
DOIs
StatePublished - Jan 23 2019

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • Anion-binding
  • Brønsted acid catalysis
  • Ion-pairing
  • Organocatalysis
  • Pictet-Spengler reaction

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