Insulin-like growth factors and leukocyte telomere length: The cardiovascular health study

Robert C. Kaplan, Annette L. Fitzpatrick, Michael N. Pollak, Jeffrey P. Gardner, Nancy S. Jenny, Aileen P. McGinn, Lewis H. Kuller, Howard D. Strickler, Masayuki Kimura, Bruce M. Psaty, Abraham Aviv

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Abstract

The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number11
DOIs
StatePublished - Dec 1 2009

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All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Keywords

  • Epidemiology
  • Factor
  • Insulin-like growth
  • Telomere length

Cite this

Kaplan, R. C., Fitzpatrick, A. L., Pollak, M. N., Gardner, J. P., Jenny, N. S., McGinn, A. P., Kuller, L. H., Strickler, H. D., Kimura, M., Psaty, B. M., & Aviv, A. (2009). Insulin-like growth factors and leukocyte telomere length: The cardiovascular health study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 64(11), 1103-1106. https://doi.org/10.1093/gerona/glp036