Insulin-like growth factors and leukocyte telomere length

The cardiovascular health study

Robert C. Kaplan, Annette L. Fitzpatrick, Michael N. Pollak, Jeffrey P. Gardner, Nancy S. Jenny, Aileen P. McGinn, Lewis H. Kuller, Howard D. Strickler, Masayuki Kimura, Bruce M. Psaty, Abraham Aviv

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number11
DOIs
StatePublished - Dec 1 2009

Fingerprint

Telomere
Somatomedins
Leukocytes
Insulin-Like Growth Factor Binding Protein 1
Health
Insulin-Like Growth Factor Binding Protein 3
Linear Models
Body Mass Index
Smoking
Maintenance
Hypertension
Lipids
Serum

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Kaplan, Robert C. ; Fitzpatrick, Annette L. ; Pollak, Michael N. ; Gardner, Jeffrey P. ; Jenny, Nancy S. ; McGinn, Aileen P. ; Kuller, Lewis H. ; Strickler, Howard D. ; Kimura, Masayuki ; Psaty, Bruce M. ; Aviv, Abraham. / Insulin-like growth factors and leukocyte telomere length : The cardiovascular health study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2009 ; Vol. 64, No. 11. pp. 1103-1106.
@article{492ccbeabc124d02b00d6c35f0e298ff,
title = "Insulin-like growth factors and leukocyte telomere length: The cardiovascular health study",
abstract = "The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.",
author = "Kaplan, {Robert C.} and Fitzpatrick, {Annette L.} and Pollak, {Michael N.} and Gardner, {Jeffrey P.} and Jenny, {Nancy S.} and McGinn, {Aileen P.} and Kuller, {Lewis H.} and Strickler, {Howard D.} and Masayuki Kimura and Psaty, {Bruce M.} and Abraham Aviv",
year = "2009",
month = "12",
day = "1",
doi = "10.1093/gerona/glp036",
language = "English (US)",
volume = "64",
pages = "1103--1106",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "11",

}

Kaplan, RC, Fitzpatrick, AL, Pollak, MN, Gardner, JP, Jenny, NS, McGinn, AP, Kuller, LH, Strickler, HD, Kimura, M, Psaty, BM & Aviv, A 2009, 'Insulin-like growth factors and leukocyte telomere length: The cardiovascular health study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 64, no. 11, pp. 1103-1106. https://doi.org/10.1093/gerona/glp036

Insulin-like growth factors and leukocyte telomere length : The cardiovascular health study. / Kaplan, Robert C.; Fitzpatrick, Annette L.; Pollak, Michael N.; Gardner, Jeffrey P.; Jenny, Nancy S.; McGinn, Aileen P.; Kuller, Lewis H.; Strickler, Howard D.; Kimura, Masayuki; Psaty, Bruce M.; Aviv, Abraham.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 11, 01.12.2009, p. 1103-1106.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Insulin-like growth factors and leukocyte telomere length

T2 - The cardiovascular health study

AU - Kaplan, Robert C.

AU - Fitzpatrick, Annette L.

AU - Pollak, Michael N.

AU - Gardner, Jeffrey P.

AU - Jenny, Nancy S.

AU - McGinn, Aileen P.

AU - Kuller, Lewis H.

AU - Strickler, Howard D.

AU - Kimura, Masayuki

AU - Psaty, Bruce M.

AU - Aviv, Abraham

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

AB - The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

UR - http://www.scopus.com/inward/record.url?scp=70350458746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350458746&partnerID=8YFLogxK

U2 - 10.1093/gerona/glp036

DO - 10.1093/gerona/glp036

M3 - Article

VL - 64

SP - 1103

EP - 1106

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 11

ER -