Insulin resistance-associated interhemispheric functional connectivity alterations in T2DM: A resting-state fMRI study

Wenqing Xia, Shaohua Wang, Andrea M. Spaeth, Hengyi Rao, Pin Wang, Yue Yang, Rong Huang, Rongrong Cai, Haixia Sun

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We aim to investigate whether decreased interhemispheric functional connectivity exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, we sought to determine whether interhemispheric functional connectivity deficits associated with cognition and insulin resistance (IR) among T2DM patients. We compared the interhemispheric resting state functional connectivity of 32 T2DM patients and 30 healthy controls using rs-fMRI. Partial correlation coefficients were used to detect the relationship between rs-fMRI information and cognitive or clinical data. Compared with healthy controls, T2DM patients showed bidirectional alteration of functional connectivity in several brain regions. Functional connectivity values in the middle temporal gyrus (MTG) and in the superior frontal gyrus were inversely correlated with Trail Making Test-B score of patients. Notably, insulin resistance (log homeostasis model assessment-IR) negatively correlated with functional connectivity in the MTG of patients. In conclusion, T2DM patients exhibit abnormal interhemispheric functional connectivity in several default mode network regions, particularly in the MTG, and such alteration is associated with IR. Alterations in interhemispheric functional connectivity might contribute to cognitive dysfunction in T2DM patients.

Original languageEnglish (US)
Article number719076
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Insulin resistance-associated interhemispheric functional connectivity alterations in T2DM: A resting-state fMRI study'. Together they form a unique fingerprint.

Cite this