Integrated population balance model development and validation of a granulation process

Anwesha Chaudhury, Rohit Ramachandran

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This study is concerned with the development of an integrated three-dimensional population balance model (PBM) that describes the combined effect of key granulation mechanisms that occur during the course of a granulation process. Results demonstrate the importance of simulating the different mechanisms within a population balance model framework to elucidate realistic granulation dynamics. The incorporation of liquid addition in the model also aids in demarcating the dynamics in different regimes such as premixing, granulation (during liquid addition) and wet massing (after liquid addition). For the first time, the effect of primary particle size distributions and mode of binder addition on key granule properties was studied using an integrated PBM. Experimental data confirms the validity of the overall model as compared to traditional models in the literature that do not integrate the different granulation mechanisms.

Original languageEnglish (US)
Pages (from-to)407-418
Number of pages12
JournalParticulate Science and Technology
Issue number4
StatePublished - Apr 7 2013

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


  • Aggregation
  • Breakage
  • Granulation
  • Multi-dimensional population balance model
  • Simulation

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