Integrative/hybrid methods structural biology: Role of macromolecular crystallography

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Macromolecular crystallography has been central to the emergence and development of structural biology as a scientific discipline. Approximately 90% of the more than 138,000 three-dimensional structures currently available in the Protein Data Bank (PDB) archive, the single, global open access data resource for macromolecular structure data, were determined using X-ray crystallography. MX, the enormous variety of PDB structures of proteins, DNA, and RNA, and computational models derived therefrom will be central to the growth of integrative or hybrid (I/H) methods structural studies of macromolecular assemblies and other complex biological systems.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages11-18
Number of pages8
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1105
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Crystallography
Databases
Proteins
X ray crystallography
X Ray Crystallography
Biological systems
RNA
DNA
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • 3D structure
  • Atomic coordinates
  • DNA
  • I/H methods
  • Integrative/hybrid methods
  • MX
  • Macromolecular crystallography
  • PDB
  • Protein
  • Protein crystallography
  • Protein data bank
  • RNA
  • Structural biology
  • Worldwide protein data bank
  • X-ray crystallography
  • wwPDB

Cite this

Burley, S. (2018). Integrative/hybrid methods structural biology: Role of macromolecular crystallography. In Advances in Experimental Medicine and Biology (pp. 11-18). (Advances in Experimental Medicine and Biology; Vol. 1105). Springer New York LLC. https://doi.org/10.1007/978-981-13-2200-6_2
Burley, Stephen. / Integrative/hybrid methods structural biology : Role of macromolecular crystallography. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 11-18 (Advances in Experimental Medicine and Biology).
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Burley, S 2018, Integrative/hybrid methods structural biology: Role of macromolecular crystallography. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1105, Springer New York LLC, pp. 11-18. https://doi.org/10.1007/978-981-13-2200-6_2

Integrative/hybrid methods structural biology : Role of macromolecular crystallography. / Burley, Stephen.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 11-18 (Advances in Experimental Medicine and Biology; Vol. 1105).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Burley S. Integrative/hybrid methods structural biology: Role of macromolecular crystallography. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 11-18. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-2200-6_2