Integrative/hybrid methods structural biology: Role of macromolecular crystallography

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Macromolecular crystallography has been central to the emergence and development of structural biology as a scientific discipline. Approximately 90% of the more than 138,000 three-dimensional structures currently available in the Protein Data Bank (PDB) archive, the single, global open access data resource for macromolecular structure data, were determined using X-ray crystallography. MX, the enormous variety of PDB structures of proteins, DNA, and RNA, and computational models derived therefrom will be central to the growth of integrative or hybrid (I/H) methods structural studies of macromolecular assemblies and other complex biological systems.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages8
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


  • 3D structure
  • Atomic coordinates
  • DNA
  • I/H methods
  • Integrative/hybrid methods
  • MX
  • Macromolecular crystallography
  • PDB
  • Protein
  • Protein crystallography
  • Protein data bank
  • RNA
  • Structural biology
  • Worldwide protein data bank
  • X-ray crystallography
  • wwPDB


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