Integrative/hybrid methods structural biology: Role of macromolecular crystallography

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Macromolecular crystallography has been central to the emergence and development of structural biology as a scientific discipline. Approximately 90% of the more than 138,000 three-dimensional structures currently available in the Protein Data Bank (PDB) archive, the single, global open access data resource for macromolecular structure data, were determined using X-ray crystallography. MX, the enormous variety of PDB structures of proteins, DNA, and RNA, and computational models derived therefrom will be central to the growth of integrative or hybrid (I/H) methods structural studies of macromolecular assemblies and other complex biological systems.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages11-18
Number of pages8
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1105
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • 3D structure
  • Atomic coordinates
  • DNA
  • I/H methods
  • Integrative/hybrid methods
  • MX
  • Macromolecular crystallography
  • PDB
  • Protein
  • Protein crystallography
  • Protein data bank
  • RNA
  • Structural biology
  • Worldwide protein data bank
  • X-ray crystallography
  • wwPDB

Fingerprint Dive into the research topics of 'Integrative/hybrid methods structural biology: Role of macromolecular crystallography'. Together they form a unique fingerprint.

  • Cite this

    Burley, S. K. (2018). Integrative/hybrid methods structural biology: Role of macromolecular crystallography. In Advances in Experimental Medicine and Biology (pp. 11-18). (Advances in Experimental Medicine and Biology; Vol. 1105). Springer New York LLC. https://doi.org/10.1007/978-981-13-2200-6_2