Interaction of a host protein with core complexes of bacteriophage Φ6 to control transcription

Xueying Qiao, Yang Sun, Jian Qiao, Leonard Mindich

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Bacteriophages of the family Cystoviridae have genomes consisting of three double-stranded RNA (dsRNA) segments, L, S, and M, packaged within a polyhedral capsid along with RNA polymerase. Transcription of genomic segment L is activated by the interaction of host protein YajQ with the capsid structure. Segment L codes for the proteins of the inner capsid, which are expressed early in infection. Green fluorescent protein (GFP) fusions with YajQ produce uniform fluorescence in uninfected cells and in cells infected with viruses not dependent on YajQ. Punctate fluorescence develops when cells are infected with YajQ-dependent viruses. It appears that the host protein binds to the infecting particles and remains with them during the entire infection period.

Original languageEnglish (US)
Pages (from-to)4821-4825
Number of pages5
JournalJournal of virology
Issue number9
StatePublished - May 2010

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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