@inbook{393cb17d32f8423fb3421ab1ecc7fe3c,
title = "Interaction of ricin and Shiga toxins with ribosomes",
abstract = "Ricin and Shiga toxins designated as ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine (A 4324 in rat 28S rRNA) in the conserved α-sarcin/ricin loop of the large rRNA, inhibiting protein synthesis. Evidence obtained from a number of studies suggests that interaction with ribosomal proteins plays an important role in the catalytic activity and ribosome specificity of RIPs. This review summarizes the recent developments in identification of the ribosomal proteins that interact with ricin and Shiga toxins and the principles governing these interactions.",
keywords = "Ribosomal stalk, Ribosome binding, Ribosome depurination, Ricin, Sarcin ricin loop, Shiga toxin, Translation inhibition",
author = "Tumer, {Nilgun E.} and Li, {Xiao Ping}",
note = "Funding Information: This work was supported by National Institutes of Health grants AI072425 and AI082120.",
year = "2012",
doi = "10.1007/82_2011_174",
language = "English (US)",
isbn = "9783642274695",
series = "Current Topics in Microbiology and Immunology",
pages = "1--18",
editor = "Nicholas Mantis and Nicholas Mantis",
booktitle = "Ricin and Shiga Toxins",
}