Interaction of ricin and Shiga toxins with ribosomes

Nilgun E. Tumer, Xiao Ping Li

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations


Ricin and Shiga toxins designated as ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine (A 4324 in rat 28S rRNA) in the conserved α-sarcin/ricin loop of the large rRNA, inhibiting protein synthesis. Evidence obtained from a number of studies suggests that interaction with ribosomal proteins plays an important role in the catalytic activity and ribosome specificity of RIPs. This review summarizes the recent developments in identification of the ribosomal proteins that interact with ricin and Shiga toxins and the principles governing these interactions.

Original languageEnglish (US)
Title of host publicationRicin and Shiga Toxins
Subtitle of host publicationPathogenesis, Immunity, Vaccines and Therapeutics
EditorsNicholas Mantis, Nicholas Mantis
Number of pages18
StatePublished - 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070-217X

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


  • Ribosomal stalk
  • Ribosome binding
  • Ribosome depurination
  • Ricin
  • Sarcin ricin loop
  • Shiga toxin
  • Translation inhibition


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