Interaction of slow cortical rhythm with somatosensory information processing in urethane-anesthetized rats

Attila Toth, Erika Gyengesi, Laszlo Zaborszky, Laszlo Detari

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Slow cortical rhythm (SCR) is a rhythmic alteration of active (hypopolarized), and silent (hyperpolarized) epochs in cortical cells. SCR was found to influence sensory information processing in various models, but these studies yielded inconsistent results. We examined sensory processing in anesthetized rats during SCR by recording multiple unit activity (MUA) and evoked field potentials (eFPs). Evoked field potentials as well as spontaneous FP changes around spontaneous activations were analyzed by subsequent current source density (CSD) analysis. MUA responses and eFPs were recorded from the hindlimb area (HL) of the somatosensory cortex (SI) to electrical stimuli of the tibial nerve during active and silent states, respectively. Stimulus-associated MUA above the ongoing background activity did not differ significantly in active vs. silent states. Short-latency (< 50 ms) eFP responses consisted of a sequence of deep-negative and deep-positive waves. Parameters of the first negative deflection were similar in both states. Stimulation in the silent state occasionally induced 500-700 ms long spindles in the alpha range (10-16 Hz). Spindles were never observed in responses to active state stimulation. CSD analysis showed moderately different cortical sink-source patterns when the stimulus was applied during active vs. silent state. Sinks first appeared in layer IV, V and VI, corresponding sources were in layer I/II, V and VI. Stronger activation appeared in the infraganular layers in the case of active state. CSD of spontaneous FPs revealed some sequential activation pattern in the cortex when strongest and earlier sink appeared in layer III during active states.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalBrain research
Volume1226
DOIs
StatePublished - Aug 21 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Current source density analysis
  • Evoked field potential
  • Hindlimb area
  • Rat
  • Slow cortical rhythm
  • Somatosensory cortex

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