Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

Hyung J. Ahn, Zu Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalCurrent Opinion in Hematology
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2017

All Science Journal Classification (ASJC) codes

  • Hematology

Keywords

  • Alzheimer's disease
  • factor XII
  • fibrinogen
  • β-amyloid peptide

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