Interfacial ring-opening polymerization of amino-acid-derived N-thiocarboxyanhydrides toward well-defined polypeptides

Jinbao Cao, David Siefker, Brandon A. Chan, Tianyi Yu, Lu Lu, Mirza A. Saputra, Frank R. Fronczek, Weiwei Xie, Donghui Zhang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Interfacial ring-opening polymerizations (iROP) of α-amino-acid derived N-thiocarboxyanhydrides (NTAs) in hexanes or heptane suspension using soluble primary amine initiators have been demonstrated to produce polypeptides with controlled molecular weight and low-tomoderate molecular weight distribution under mild conditions. The NTA monomers were shown to have significantly enhanced moisture and thermal stability relative to Ncarboxyanhydrides (NCAs), resulting in long shelf life and allowing the polymerization to occur quantitatively in open air.

Original languageEnglish (US)
Pages (from-to)836-840
Number of pages5
JournalACS Macro Letters
Volume6
Issue number8
DOIs
StatePublished - Aug 15 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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