Interferon-β signaling contributes to ras transformation

Yu Chen Tsai, Sidney Pestka, Lu Hai Wang, Loren W. Runnels, Shan Wan, Yi Lisa Lyu, Leroy F. Liu

Research output: Contribution to journalArticle

22 Scopus citations


Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-β signaling. Significantly, elevated IFN-β signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-β, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.

Original languageEnglish (US)
Article numbere24291
JournalPloS one
Issue number8
StatePublished - Aug 29 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Interferon-β signaling contributes to ras transformation'. Together they form a unique fingerprint.

  • Cite this

    Tsai, Y. C., Pestka, S., Wang, L. H., Runnels, L. W., Wan, S., Lyu, Y. L., & Liu, L. F. (2011). Interferon-β signaling contributes to ras transformation. PloS one, 6(8), [e24291].