Interferon beta-1b-induced postmenopausal bleeding in a patient with multiple sclerosis

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Objective: Postmenopausal bleeding must always be evaluated to rule out endometrial carcinoma, although there are many benign etiologies. There have been rare reports of premenopausal bleeding with interferon beta-1b, used to treat multiple sclerosis, but no prior reports in postmenopausal women. Methods: Literature searches were performed using PubMed and Medline for articles with content related to premenopausal and postmenopausal bleeding while taking interferon beta-1b. The searches were restricted to the English language. Search terms included interferon beta-1b and/or uterine hemorrhage and/or vaginal bleeding and/or postmenopausal and/or menopause. Results: The literature review found no related articles for postmenopausal bleeding while taking interferon beta-1b. We present a case of a patient with postmenopausal bleeding attributed to elevation of serum estradiol in association with interferon beta-1b therapy. Conclusion: It is important for patients and providers to be aware of the association between postmenopausal bleeding with the use of interferon beta-1b therapy which could be due to elevated serum estradiol levels.

Original languageEnglish (US)
Pages (from-to)599-600
Number of pages2
Issue number6
StatePublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology


  • Interferon-beta/adverse effects
  • Interferon-beta/therapeutic use
  • multiple sclerosis/drug therapy
  • postmenopausal bleeding

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