Startle measures were taken 2 h following a systemic injection of interleukin-1β (IL-1β) (3 μg/kg) to intact or ovariectomy (OVX) female rats. Changes in startle responsivity (reduced startle magnitude) were evident in intact IL-1β-treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL-1β-treated OVX rats. These results are discussed as a possible mechanism for stress-induced suppression of startle responsivity seen in intact female rats.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
- Sex differences