Interleukin-1β as a mechanism for stress-induced startle suppression in females

Kevin D. Beck, Richard J. Servatius

Research output: Contribution to journalArticle

5 Scopus citations


Startle measures were taken 2 h following a systemic injection of interleukin-1β (IL-1β) (3 μg/kg) to intact or ovariectomy (OVX) female rats. Changes in startle responsivity (reduced startle magnitude) were evident in intact IL-1β-treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL-1β-treated OVX rats. These results are discussed as a possible mechanism for stress-induced suppression of startle responsivity seen in intact female rats.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalAnnals of the New York Academy of Sciences
StatePublished - Jul 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


  • Behavior
  • Cytokines
  • Sex differences
  • Stress

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