Intestinal transport during fasting and malnutrition

R. P. Ferraris, H. V. Carey

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


Fasting or malnutrition (FM) has dramatic effects on small intestinal mucosal structure and transport function. Intestinal secretion of ions and fluid is increased by FM both under basal conditions and in response to secretory agonists. Intestinal permeability to ions and macromolecules may also be elevated by FM, which increases the potential for fluid and electrolyte losses and for anaphylactic responses to luminal antigens. Mucosal atrophy induced by FM reduces total intestinal absorption of nutrients, but nutrient absorption normalized to mucosal mass may actually be enhanced by a variety of mechanisms, including increased transporter gene expression, electrochemical gradients, and ratio of mature to immature cells. These observations underscore the value of enteral feeding during health and disease.

Original languageEnglish (US)
Pages (from-to)195-219
Number of pages25
JournalAnnual Review of Nutrition
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


  • Absorption
  • Electrolytes
  • Mucosa
  • Nutrients
  • Permeability
  • Secretion

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