Intracellular Ca2+ and adaptation of voltage responses to light in Hermissenda photoreceptors

I. A. Muzzio, A. C. Talk, Louis Matzel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fluorescent Imaging of Ca2+ and intracellular recordings were used to assess Ca2+ increases and voltage responses during light presentations in Hermissenda B photoreceptors. Ca2+ levels increased and were sustained during a relatively long exposure to light. Repeated presentations of a brief light induced an elevation of intracellular Ca2+ that persisted throughout short interlight intervals, but which dissipated during long interlight intervals. In all instances, the magnitude of the intracellular Ca2+ signal was inversely related to the amplitude of the light-induced generator potential. Blocking of voltage-dependent Ca2+ channels did not significantly affect the magnitude of the Ca2+ signal, suggesting that the intracellular Ca2+ response arises primarily from release from intracellular stores. These results indicate that Ca2+ plays an important role in the modulation of the voltage responses to light, acting to suppress the response during repetitive or prolonged stimulation.

Original languageEnglish (US)
Pages (from-to)1625-1631
Number of pages7
JournalNeuroReport
Volume9
Issue number7
DOIs
StatePublished - May 11 1998

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Hermissenda
Light

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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abstract = "Fluorescent Imaging of Ca2+ and intracellular recordings were used to assess Ca2+ increases and voltage responses during light presentations in Hermissenda B photoreceptors. Ca2+ levels increased and were sustained during a relatively long exposure to light. Repeated presentations of a brief light induced an elevation of intracellular Ca2+ that persisted throughout short interlight intervals, but which dissipated during long interlight intervals. In all instances, the magnitude of the intracellular Ca2+ signal was inversely related to the amplitude of the light-induced generator potential. Blocking of voltage-dependent Ca2+ channels did not significantly affect the magnitude of the Ca2+ signal, suggesting that the intracellular Ca2+ response arises primarily from release from intracellular stores. These results indicate that Ca2+ plays an important role in the modulation of the voltage responses to light, acting to suppress the response during repetitive or prolonged stimulation.",
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Intracellular Ca2+ and adaptation of voltage responses to light in Hermissenda photoreceptors. / Muzzio, I. A.; Talk, A. C.; Matzel, Louis.

In: NeuroReport, Vol. 9, No. 7, 11.05.1998, p. 1625-1631.

Research output: Contribution to journalArticle

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