In this chapter we discuss the current understanding of the development of myeloid cells from hematopoietic stem cells (HSC), step-wise to their mature forms: granulocytes and monocytes. We delineate the characteristics of mature myeloid cells and show which transcription factors are necessary for their appearance. We also describe cytokines, signal transduction pathways and microRNAs (miRNAs) which modulate expression and activities of transcription factors that drive myeloid differentiation of HSC.
|Original language||English (US)|
|Title of host publication||Cell Determination during Hematopoiesis|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||25|
|State||Published - 2009|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)