Intracellular signaling for granulocytic and monocytic differentiation

George P. Studzinski, Ewa Marcinkowska

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In this chapter we discuss the current understanding of the development of myeloid cells from hematopoietic stem cells (HSC), step-wise to their mature forms: granulocytes and monocytes. We delineate the characteristics of mature myeloid cells and show which transcription factors are necessary for their appearance. We also describe cytokines, signal transduction pathways and microRNAs (miRNAs) which modulate expression and activities of transcription factors that drive myeloid differentiation of HSC.

Original languageEnglish (US)
Title of host publicationCell Determination during Hematopoiesis
PublisherNova Science Publishers, Inc.
Number of pages25
ISBN (Print)9781607417330
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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