The effect of lidocaine given intramuscularly upon the blood levels and its effect in the abolition of ventricular arrhythmias were studied. Only slight antiarrhythmic effects were noted after the intramuscular injection of 200 mg of lidocaine; the mean serum level ranged from 1.3 to 1.9 μg/ml. In 10 adult patients with various types of heart disease presenting frequent premature contraction (> 6/min), 300 mg of lidocaine was injected intramuscularly. The premature ventricular contractions were abolished for at least 45 minutes after administration of lidocaine in 8 patients, and their frequency was markedly reduced in the other 2 patients. During this period the serum level of lidocaine was 2.4 to 2.8 μg/ml. No notable side effects were noted. The antiarrhythmic effect subsided progressively after 45 to 60 minutes. These findings have implications for the administration of lidocaine in settings where intravenous infusion may not be feasible or practical.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine