Intrapatient Variability of the Human Immunodeficiency Virus Type 2 Envelope V3 Loop

Jean Louis Sankalé, Roberto Allier Tour, Boris Renjifo, Tidiane Siby, Souleymane Mboup, Richard G. Marlink, Max E. Essex, Phyllis J. Kanki

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Studies of HIV-2 infection have shown lower rates of sexual and perinatal transmission and a prolonged incubation period to AIDS as compared to HIV-1. To evaluate the role of genetic variation in HIV pathogenesis, we studied intrapatient variability in the V3 loop of the HIV-2 envelope gene over time in five seropositive individuals. Proviral sequences derived from uncultured PBMC DNA (n = 102) demonstrated an average sequence heterogeneity within a sample of 1.4% (0-4.1%). This was significantly lower than the V3 sequence heterogeneity observed in HIV-1, which can be as high as 6.1%. In HIV-2-seropositive healthy patients the average intrapatient nucleotide variability rate was 0.6% compared to 2.0% in patients with clinical AIDS. The lower rate of variability between HIV-2 and HIV-1 is compatible with differences in transmission and pathogenesis of these two related viruses.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalAIDS research and human retroviruses
Volume11
Issue number5
DOIs
StatePublished - May 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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