Intravenous Methotrexate for Treatment of Interstitial Pregnancy: A Case Report

Anthony Al-Khan, Roger Jones, Donald Fricchione, Joseph Apuzzio

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


BACKGROUND: Ectopic pregnancy is the leading cause of first-trimester maternal death, accounting for 9% of pregnancy-related deaths. Interstitial (cornual) pregnancies represent 6% of all ectopics but account for a disproportionately higher mortality rate. Surgical management has been the treatment of choice for interstitial pregnancies. A very limited number of articles have explored the use of intravenous methotrexate to treat cornual pregnancy as a possible conservative first-line therapy in selected, hemodynamically stable patients. CASE: A patient with a confirmed interstitial pregnancy was treated with intravenous methotrexate. The patient's β-hCG levels decreased to zero within 9 weeks. CONCLUSION: Intravenous methotrexate was used successfully in the treatment of an interstitual pregnancy without complications.

Original languageEnglish (US)
Pages (from-to)121-122
Number of pages2
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number2
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology


  • Methotrexate
  • Pregancy, ectopic

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