@article{05cd1c48b1474706a1466f616b47aacf,
title = "Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers",
abstract = "We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific and nonspecific metabolites of organophosphates (OPs), pyrethroids, select herbicides, and fungicides. Serum was analyzed for total and free testosterone. Linear regression analyses revealed significant negative relationships between total testosterone and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) after controlling for covariates (eg, age, BMI, smoking status). Positive significant associations were found between some OP pesticides and total testosterone. Due to the small sample size and the observational nature of the study, future investigation is needed to confirm our results and to elucidate the biological mechanisms.",
keywords = "Endocrine disruptor, exposures, farmers, pesticides, reproductive health, testosterone",
author = "Parinya Panuwet and Chandresh Ladva and Barr, {Dana Boyd} and Tippawan Prapamontol and Meeker, {John D.} and D'Souza, {Priya Esilda} and H{\'e}ctor Maldonado and Ryan, {P. Barry} and Robson, {Mark G.}",
note = "Funding Information: This work was partially supported by HERCULES: The Expo-some Research Center (NIH/NIEHS P30 ES019776), Center for Environmental Exposures and Disease (NIH/NIEHS P30 ES005022) at Rutgers, the New Jersey Agricultural Experiment Station, ITREOH Center (NIH Fogarty D43 TW007849), Early Pesticide Exposure and Neurodevelopmental Outcomes in a Thai Birth Cohort (NIH/NIEHS R21 ES015465-01A2), and Impact of Prenatal Insecticide Exposure on Neurodevelopmen-tal Trajectories in a Thai Birth Cohort: Building Exposure Science and Neurodevelopmental Research Capacity in Thailand (NIH/NIEHS 1R01 ES026082-01A1). Analysis of urinary biomarkers of pesticides was supported by the U.S. Centers for Disease Control and Prevention. During the time in which the manuscript was being prepared, Dr. Panuwet was supported by the fellowship program of the International Agency for Research on Cancer (IARC) and the European Union Co-funding of regional, national, and international programs (2014–2016). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis.",
year = "2018",
month = jul,
day = "4",
doi = "10.1080/19338244.2017.1378606",
language = "English (US)",
volume = "73",
pages = "205--218",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Heldref Publications",
number = "4",
}