Iron Replacement in Patients with Inflammatory Bowel Disease and Nonanemic Iron Deficiency: What Is the Clinical Significance?

Poor iron status is a frequent issue among patients with inflammatory bowel disease (IBD), regardless of whether anemia is present. However, clear guidelines on iron supplementation in patients with iron deficiency but without anemia are lacking. This review discusses recent trials on the effect of iron replacement therapy on quality of life and laboratory indices in adult patients with IBD and iron deficiency in the absence of anemia. Limited studies suggest that intravenous iron may improve quality of life and is relatively safe, but further research is warranted. Areas for future research and suggestions for current practice are highlighted.