Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices

Kiana Aran, Lawrence A. Sasso, Neal Kamdar, Jeffrey D. Zahn

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


A method for integrating porous polymer membranes such as polycarbonate, polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The use of 3-aminopropyltriethoxysilane as a chemical crosslinking agent was extended to integrate membranes with PDMS and glass microfluidic channels. A strong, irreversible bond between the membranes and microfluidic structure was achieved. The bonding strength in the APTES treated devices was significantly greater than in devices fabricated using either a PDMS "glue" or two-part epoxy bonding method. Evaluation of a filtering microdevice and the pore structure via SEM indicates the APTES conjugation does not significantly alter the membrane transport function and pore morphology.

Original languageEnglish (US)
Pages (from-to)548-552
Number of pages5
JournalLab on a Chip
Issue number5
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering


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