Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?

J. Barwell, L. Pangon, A. Georgiou, Z. Docherty, I. Kesterton, J. Ball, R. Camplejohn, J. Berg, A. Aviv, J. Gardner, B. S. Kato, N. Carter, D. Paximadas, T. D. Spector, S. Hodgson

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mean terminal restriction fragment (TRF) lengths in white blood cells (WBCs) have been previously found to be associated with breast cancer. To assess whether this marker could be used as a test for breast cancer susceptibility in women, TRF length was measured in 72 treated female breast cancer patients and 1696 unaffected female controls between the ages of 45 and 77 from the Twin Research Unit at St Thomas' Hospital, as well as 140 newly diagnosed breast cancer cases and 108 mammographically screened unaffected controls from Guy's Hospital. Mean TRF was also tested for correlation with chromosome radiosensitivity and apoptotic response in the Guy's Hospital patients. After adjusting for age, smoking and body mass index, there was no significant difference in TRF lengths between the treated breast cancer patients and unaffected controls (P=0.71). A positive correlation between age-adjusted apoptotic response and mean TRF in newly diagnosed untreated breast cancer patients (P=0.008) was identified but no significant difference in TRF lengths between breast cancer patients and unaffected controls was detected (P=0.53). This suggests that TRF lengths in WBC, is not a marker of breast cancer susceptibility and does not vary significantly between affected women before and after treatment.

Original languageEnglish (US)
Pages (from-to)1696-1700
Number of pages5
JournalBritish Journal of Cancer
Volume97
Issue number12
DOIs
StatePublished - Dec 17 2007

Fingerprint

Radiation Tolerance
Telomere
Lymphocytes
Breast Neoplasms
Neoplasms
Leukocytes
Body Mass Index
Chromosomes
Smoking
Research

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Apoptosis
  • Breast cancer susceptibility
  • Chromosome
  • Radiosensitivity
  • Telomere

Cite this

Barwell, J., Pangon, L., Georgiou, A., Docherty, Z., Kesterton, I., Ball, J., ... Hodgson, S. (2007). Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? British Journal of Cancer, 97(12), 1696-1700. https://doi.org/10.1038/sj.bjc.6604085
Barwell, J. ; Pangon, L. ; Georgiou, A. ; Docherty, Z. ; Kesterton, I. ; Ball, J. ; Camplejohn, R. ; Berg, J. ; Aviv, A. ; Gardner, J. ; Kato, B. S. ; Carter, N. ; Paximadas, D. ; Spector, T. D. ; Hodgson, S. / Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?. In: British Journal of Cancer. 2007 ; Vol. 97, No. 12. pp. 1696-1700.
@article{fe98568e6a2144e0adfba3a9c994bd0c,
title = "Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?",
abstract = "Mean terminal restriction fragment (TRF) lengths in white blood cells (WBCs) have been previously found to be associated with breast cancer. To assess whether this marker could be used as a test for breast cancer susceptibility in women, TRF length was measured in 72 treated female breast cancer patients and 1696 unaffected female controls between the ages of 45 and 77 from the Twin Research Unit at St Thomas' Hospital, as well as 140 newly diagnosed breast cancer cases and 108 mammographically screened unaffected controls from Guy's Hospital. Mean TRF was also tested for correlation with chromosome radiosensitivity and apoptotic response in the Guy's Hospital patients. After adjusting for age, smoking and body mass index, there was no significant difference in TRF lengths between the treated breast cancer patients and unaffected controls (P=0.71). A positive correlation between age-adjusted apoptotic response and mean TRF in newly diagnosed untreated breast cancer patients (P=0.008) was identified but no significant difference in TRF lengths between breast cancer patients and unaffected controls was detected (P=0.53). This suggests that TRF lengths in WBC, is not a marker of breast cancer susceptibility and does not vary significantly between affected women before and after treatment.",
keywords = "Apoptosis, Breast cancer susceptibility, Chromosome, Radiosensitivity, Telomere",
author = "J. Barwell and L. Pangon and A. Georgiou and Z. Docherty and I. Kesterton and J. Ball and R. Camplejohn and J. Berg and A. Aviv and J. Gardner and Kato, {B. S.} and N. Carter and D. Paximadas and Spector, {T. D.} and S. Hodgson",
year = "2007",
month = "12",
day = "17",
doi = "10.1038/sj.bjc.6604085",
language = "English (US)",
volume = "97",
pages = "1696--1700",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "12",

}

Barwell, J, Pangon, L, Georgiou, A, Docherty, Z, Kesterton, I, Ball, J, Camplejohn, R, Berg, J, Aviv, A, Gardner, J, Kato, BS, Carter, N, Paximadas, D, Spector, TD & Hodgson, S 2007, 'Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?', British Journal of Cancer, vol. 97, no. 12, pp. 1696-1700. https://doi.org/10.1038/sj.bjc.6604085

Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? / Barwell, J.; Pangon, L.; Georgiou, A.; Docherty, Z.; Kesterton, I.; Ball, J.; Camplejohn, R.; Berg, J.; Aviv, A.; Gardner, J.; Kato, B. S.; Carter, N.; Paximadas, D.; Spector, T. D.; Hodgson, S.

In: British Journal of Cancer, Vol. 97, No. 12, 17.12.2007, p. 1696-1700.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?

AU - Barwell, J.

AU - Pangon, L.

AU - Georgiou, A.

AU - Docherty, Z.

AU - Kesterton, I.

AU - Ball, J.

AU - Camplejohn, R.

AU - Berg, J.

AU - Aviv, A.

AU - Gardner, J.

AU - Kato, B. S.

AU - Carter, N.

AU - Paximadas, D.

AU - Spector, T. D.

AU - Hodgson, S.

PY - 2007/12/17

Y1 - 2007/12/17

N2 - Mean terminal restriction fragment (TRF) lengths in white blood cells (WBCs) have been previously found to be associated with breast cancer. To assess whether this marker could be used as a test for breast cancer susceptibility in women, TRF length was measured in 72 treated female breast cancer patients and 1696 unaffected female controls between the ages of 45 and 77 from the Twin Research Unit at St Thomas' Hospital, as well as 140 newly diagnosed breast cancer cases and 108 mammographically screened unaffected controls from Guy's Hospital. Mean TRF was also tested for correlation with chromosome radiosensitivity and apoptotic response in the Guy's Hospital patients. After adjusting for age, smoking and body mass index, there was no significant difference in TRF lengths between the treated breast cancer patients and unaffected controls (P=0.71). A positive correlation between age-adjusted apoptotic response and mean TRF in newly diagnosed untreated breast cancer patients (P=0.008) was identified but no significant difference in TRF lengths between breast cancer patients and unaffected controls was detected (P=0.53). This suggests that TRF lengths in WBC, is not a marker of breast cancer susceptibility and does not vary significantly between affected women before and after treatment.

AB - Mean terminal restriction fragment (TRF) lengths in white blood cells (WBCs) have been previously found to be associated with breast cancer. To assess whether this marker could be used as a test for breast cancer susceptibility in women, TRF length was measured in 72 treated female breast cancer patients and 1696 unaffected female controls between the ages of 45 and 77 from the Twin Research Unit at St Thomas' Hospital, as well as 140 newly diagnosed breast cancer cases and 108 mammographically screened unaffected controls from Guy's Hospital. Mean TRF was also tested for correlation with chromosome radiosensitivity and apoptotic response in the Guy's Hospital patients. After adjusting for age, smoking and body mass index, there was no significant difference in TRF lengths between the treated breast cancer patients and unaffected controls (P=0.71). A positive correlation between age-adjusted apoptotic response and mean TRF in newly diagnosed untreated breast cancer patients (P=0.008) was identified but no significant difference in TRF lengths between breast cancer patients and unaffected controls was detected (P=0.53). This suggests that TRF lengths in WBC, is not a marker of breast cancer susceptibility and does not vary significantly between affected women before and after treatment.

KW - Apoptosis

KW - Breast cancer susceptibility

KW - Chromosome

KW - Radiosensitivity

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=37049018196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049018196&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6604085

DO - 10.1038/sj.bjc.6604085

M3 - Article

C2 - 18000505

AN - SCOPUS:37049018196

VL - 97

SP - 1696

EP - 1700

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 12

ER -