Ischemic preconditioning of the liver: A few perspectives from the bench to bedside translation

Kunj K. Desai, George S. Dikdan, Asif Shareef, Baburao Koneru

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Utilization of ischemic preconditioning to ameliorate ischemia/ reperfusion injury has been extensively studied in various organs and species for the past two decades. While hepatic ischemic preconditioning in animals has been largely beneficial, translational efforts in the two clinical contexts - liver resection and decreased donor liver transplantation - have yielded mixed results. This review is intended to critically examine the translational data and identify some potential reasons for the disparate clinical results, and highlight some issues for further studies.

Original languageEnglish (US)
Pages (from-to)1569-1577
Number of pages9
JournalLiver Transplantation
Volume14
Issue number11
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

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