Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells

C. Rodriguez-Saona; J. G. Millar; J. T. Trumble

doi:10.1021/np980127q

Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells

C. Rodriguez-Saona, J. G. Millar, J. T. Trumble

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A new compound, (12Z,15Z)-1-hydroxy-4-oxo-heneicosa-12,15-dien-2-yl acetate, isopersin (2), has been isolated from avocado idioblast oil cells. In artificial diet bioassays, 2 showed no effects on either larval survivorship or growth of early-instar beet armyworm Spodoptera exigua. In contrast, the isomeric persin (1), (12Z,15Z)-1-acetoxy-2-hydroxy-4-oxo- heneicosa-12,15-diene, reduces larval growth at equivalent concentrations (500 μg g^-1). Compound 2 is not very stable and isomerizes readily to 1. Both compounds are acid-labile, rearranging rapidly to alkylfuran 3 in the presence of traces of acid.

Original language	English (US)
Pages (from-to)	1168-1170
Number of pages	3
Journal	Journal of Natural Products
Volume	61
Issue number	9
DOIs	https://doi.org/10.1021/np980127q
State	Published - Sep 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells",

abstract = "A new compound, (12Z,15Z)-1-hydroxy-4-oxo-heneicosa-12,15-dien-2-yl acetate, isopersin (2), has been isolated from avocado idioblast oil cells. In artificial diet bioassays, 2 showed no effects on either larval survivorship or growth of early-instar beet armyworm Spodoptera exigua. In contrast, the isomeric persin (1), (12Z,15Z)-1-acetoxy-2-hydroxy-4-oxo- heneicosa-12,15-diene, reduces larval growth at equivalent concentrations (500 μg g-1). Compound 2 is not very stable and isomerizes readily to 1. Both compounds are acid-labile, rearranging rapidly to alkylfuran 3 in the presence of traces of acid.",

author = "C. Rodriguez-Saona and Millar, {J. G.} and Trumble, {J. T.}",

year = "1998",

month = sep,

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language = "English (US)",

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T1 - Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells

AU - Rodriguez-Saona, C.

AU - Millar, J. G.

AU - Trumble, J. T.

PY - 1998/9

Y1 - 1998/9

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AB - A new compound, (12Z,15Z)-1-hydroxy-4-oxo-heneicosa-12,15-dien-2-yl acetate, isopersin (2), has been isolated from avocado idioblast oil cells. In artificial diet bioassays, 2 showed no effects on either larval survivorship or growth of early-instar beet armyworm Spodoptera exigua. In contrast, the isomeric persin (1), (12Z,15Z)-1-acetoxy-2-hydroxy-4-oxo- heneicosa-12,15-diene, reduces larval growth at equivalent concentrations (500 μg g-1). Compound 2 is not very stable and isomerizes readily to 1. Both compounds are acid-labile, rearranging rapidly to alkylfuran 3 in the presence of traces of acid.

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Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells

Abstract

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