Isolation of a viral agent causing hematopoietic neoplasia in the soft-shell clam, Mya arenaria

John J. Oprandy, Pei W. Chang, Allan D. Pronovost, Keith R. Cooper, Robert S. Brown, Vance J. Yates

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

A virus from neoplastic soft-shell clams, Mya arenaria, has been isolated. Its morphological and physical properties are similar to those of B-type retroviruses. It is enveloped, pleomorphic, averaging 120 nm in size with an eccentric nucleoid. Possible A-type particles have also been observed. The bouyant density of the particle ranged from 1.17 to 1.18 g/cm3 and the ultraviolet absorption 260 280-nm ratio was 1.23. The virus has been shown to cause a hematopoietic neoplasm in Mya. Purified virus from neoplastic clams was innoculated into nonneoplastic clams. Most of these clams developed tumors within 2 months. Virus isolated from inoculated clams which developed neoplasia was inoculated into nonneoplastic clams. Most of these clams also developed neoplasia thus completing Koch's postulates.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Invertebrate Pathology
Volume38
Issue number1
DOIs
StatePublished - Jul 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Keywords

  • Mya arenaria
  • hematopoietic neoplasm
  • physical properties
  • retrovirus
  • transmission

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