Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells

Chun Chieh Wang, Chi Tang Ho, Shih Chieh Lee, Tzong Der Way

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Most studies of tea trees have focused on their ornamental properties, there are fewer published studies on their medical values. The purpose of this study was to compare the chemical constituents and the biological potential of the water extract of leaves in eight species of Camellia including Camellia sinensis. Among eight Camellia species, Camellia sasanqua showed potent anticancer activities in prostate cancer PC3 cells. In addition to catechins, the major component, eugenyl β-primeveroside was detected in C. sasanqua. Eugenyl β-primeveroside blocked the progression of cell cycle at G1 phase by inducing p53 expression and further upregulating p21 expression. Moreover, eugenyl β-primeveroside induced apoptosis in PC3 prostate cancer cells. Our results suggest that C. sasanqua may have anticancer potential.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalJournal of Food and Drug Analysis
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

Keywords

  • Camellia sasanqua
  • G1 arrest
  • apoptosis
  • eugenyl β-primeveroside
  • prostate cancer

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