Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture

Raymond Teng, Thomas Dick

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Biofilm growth of Mycobacterium smegmatis was found to be unaffected at an isoniazid concentration that inhibited growth of planktonic bacilli (i.e. at isoniazid minimum inhibitory concentration=10 μg ml-1). Significant growth (50% of drug-free control) of biofilms was observed at up to 40 μg ml-1 and the MIC for biofilm growth showed an increase to up to 80 μg ml-1 isoniazid. Thus, the biofilm growth modus appears to be a strategy for replicating bacilli to evade the onslaught of antibacterials.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalFEMS Microbiology Letters
Volume227
Issue number2
DOIs
StatePublished - Oct 24 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

Keywords

  • Biofilm
  • Isoniazid
  • Mycobacterium
  • Phenotypic drug resistance

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