Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture

Raymond Teng, Thomas Dick

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Biofilm growth of Mycobacterium smegmatis was found to be unaffected at an isoniazid concentration that inhibited growth of planktonic bacilli (i.e. at isoniazid minimum inhibitory concentration=10 μg ml-1). Significant growth (50% of drug-free control) of biofilms was observed at up to 40 μg ml-1 and the MIC for biofilm growth showed an increase to up to 80 μg ml-1 isoniazid. Thus, the biofilm growth modus appears to be a strategy for replicating bacilli to evade the onslaught of antibacterials.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalFEMS Microbiology Letters
Issue number2
StatePublished - Oct 24 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics


  • Biofilm
  • Isoniazid
  • Mycobacterium
  • Phenotypic drug resistance


Dive into the research topics of 'Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture'. Together they form a unique fingerprint.

Cite this