Abstract
Solvent D2O and 18O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn2+ demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is consistent with the data.
Original language | English (US) |
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Pages (from-to) | 4462-4465 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 24 |
DOIs | |
State | Published - 2016 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry