Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+

Shuming Zhang, Hong Gu, Haoyuan Chen, Emily Strong, Edward W. Ollie, Daniel Kellerman, Danni Liang, Masaru Miyagi, Vernon E. Anderson, Joseph A. Piccirilli, Darrin M. York, Michael E. Harris

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Solvent D2O and 18O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn2+ demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is consistent with the data.

Original languageEnglish (US)
Pages (from-to)4462-4465
Number of pages4
JournalChemical Communications
Volume52
Issue number24
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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