Keratoacanthoma: A Clinico-Pathologic Enigma

Robert A. Schwartz, Tatyana Humphreys

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


BACKGROUND. Keratoacanthoma (KA) is an extraordinary entity. Once considered a benign neoplasm that resembled a highly malignant one (pseudomalignancy), it is now viewed in an opposite light as a cancer that resembles a benign neoplasm (pseudobenignity). OBJECTIVE. The goal was to delineate the malignant potential of this neoplasm based on the author's experience and a review of recent data and research and to emphasize the KA as a possible part of an autosomal dominant familial cancer syndrome, the Muir-Torre syndrome. METHODS. This is a review of the literature. RESULTS. In this work, the KA is reviewed with recent advances emphasized. CONCLUSION. KA is an abortive malignancy that rarely progresses into an invasive SCC. The KA may serve as a marker for the important autosomal dominant familial cancer syndrome, the Muir-Torre syndrome, as a result of a defective DNA mismatch repair gene.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalDermatologic Surgery
Issue number2 II
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology


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