Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

Xilin Zhao, Jian Ying Wang, Chen Xu, Yuzhi Dong, Jianfeng Zhou, John Domagala, Karl Drlica

Research output: Contribution to journalComment/debate

79 Citations (Scopus)

Abstract

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8- ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

Original languageEnglish (US)
Pages (from-to)956-958
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume42
Issue number4
StatePublished - Apr 1 1998
Externally publishedYes

Fingerprint

Fluoroquinolones
Staphylococcus aureus
DNA Topoisomerase IV
Bromine
Staphylococcus
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Zhao, X., Wang, J. Y., Xu, C., Dong, Y., Zhou, J., Domagala, J., & Drlica, K. (1998). Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones. Antimicrobial agents and chemotherapy, 42(4), 956-958.
Zhao, Xilin ; Wang, Jian Ying ; Xu, Chen ; Dong, Yuzhi ; Zhou, Jianfeng ; Domagala, John ; Drlica, Karl. / Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones. In: Antimicrobial agents and chemotherapy. 1998 ; Vol. 42, No. 4. pp. 956-958.
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Zhao, X, Wang, JY, Xu, C, Dong, Y, Zhou, J, Domagala, J & Drlica, K 1998, 'Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones', Antimicrobial agents and chemotherapy, vol. 42, no. 4, pp. 956-958.

Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones. / Zhao, Xilin; Wang, Jian Ying; Xu, Chen; Dong, Yuzhi; Zhou, Jianfeng; Domagala, John; Drlica, Karl.

In: Antimicrobial agents and chemotherapy, Vol. 42, No. 4, 01.04.1998, p. 956-958.

Research output: Contribution to journalComment/debate

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T1 - Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

AU - Zhao, Xilin

AU - Wang, Jian Ying

AU - Xu, Chen

AU - Dong, Yuzhi

AU - Zhou, Jianfeng

AU - Domagala, John

AU - Drlica, Karl

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Zhao X, Wang JY, Xu C, Dong Y, Zhou J, Domagala J et al. Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones. Antimicrobial agents and chemotherapy. 1998 Apr 1;42(4):956-958.