Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

Xilin Zhao, Jian Ying Wang, Chen Xu, Yuzhi Dong, Jianfeng Zhou, John Domagala, Karl Drlica

Research output: Contribution to journalComment/debate

79 Scopus citations

Abstract

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8- ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

Original languageEnglish (US)
Pages (from-to)956-958
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume42
Issue number4
DOIs
StatePublished - Apr 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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