C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8- ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases