Kilovoltage stereotactic radiosurgery for age-related macular degeneration: Assessment of optic nerve dose and patient effective dose

Justin Hanlon, Choonsik Lee, Erik Chell, Michael Gertner, Steven Hansen, Roger Howell, Wesley E. Bolch

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is a leading cause for vision loss for people over the age of 65 in the United States and a major health problem worldwide. Research for new treatments of the wet form of the disease using kilovoltage stereotactic radiosurgery is currently underway at Oraya Therapeutics, Inc. In the present study, the authors extend their previous computational stylized model of a single treated eye [Med. Phys. 35, 51515160 (2008)] to include full NURBS-based reference head phantoms of the adult male and female using anatomical data from ICRP Publication 89. The treatment was subsequently modeled in MCNPX 2.5 using a 1×1×1 mm3 voxelized version of the NURBS models. These models incorporated several organs of interest including the brain, thyroid, salivary glands, cranium, mandible, and cervical vertebrae. A higher resolution eye section at 0.5×0. 5×0.5 mm3 voxel resolution was extracted from the head phantoms to model smaller eye structures including the macula target, cornea, lens, vitreous humor, sclera/retina layer, and optic nerve. Due to lack of literature data on optic nerve pathways, a CT imaging study was undertaken to quantify the anatomical position of the optic nerve. The average absorbed doses to the organs of interest were below generally accepted thresholds for radiation safety. The estimated effective dose was 0.28 mSv which is comparable to diagnostic procedures such as a head radiograph and a factor of 10 lower than a head CT scan.

Original languageEnglish (US)
Pages (from-to)3671-3681
Number of pages11
JournalMedical Physics
Volume36
Issue number8
DOIs
StatePublished - Jan 1 2009

Fingerprint

Radiosurgery
Macular Degeneration
Optic Nerve
Head
Cervical Vertebrae
Vitreous Body
Sclera
Salivary Glands
Mandible
Skull
Cornea
Lenses
Publications
Retina
Thyroid Gland
Therapeutics
Radiation
Safety
Brain
Research

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Keywords

  • Age-related macular degeneration
  • Dose volume histogram
  • Effective dose
  • Eye model
  • Head model
  • Monte Carlo method
  • Optic nerve quantification
  • Stereotactic radiosurgery

Cite this

Hanlon, Justin ; Lee, Choonsik ; Chell, Erik ; Gertner, Michael ; Hansen, Steven ; Howell, Roger ; Bolch, Wesley E. / Kilovoltage stereotactic radiosurgery for age-related macular degeneration : Assessment of optic nerve dose and patient effective dose. In: Medical Physics. 2009 ; Vol. 36, No. 8. pp. 3671-3681.
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Kilovoltage stereotactic radiosurgery for age-related macular degeneration : Assessment of optic nerve dose and patient effective dose. / Hanlon, Justin; Lee, Choonsik; Chell, Erik; Gertner, Michael; Hansen, Steven; Howell, Roger; Bolch, Wesley E.

In: Medical Physics, Vol. 36, No. 8, 01.01.2009, p. 3671-3681.

Research output: Contribution to journalArticle

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