Abstract
Kisspeptins (KP), peptide products of the kisspeptin-1 (KISSI) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISSIR). KISSIR couples to the Gaq/11 signaling pathway. KISSI is a metastasis suppressor gene and the KP/KISSIR signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that KP/KISSIR pathway plays detrimental roles in breast cancer. In this review, we summarize recent developments in the understanding of the mechanisms regulating KP/KISSIR signaling in breast cancer metastasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 653-661 |
| Number of pages | 9 |
| Journal | Journal of Cancer |
| Volume | 4 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2013 |
All Science Journal Classification (ASJC) codes
- Oncology
Keywords
- Breast cancer
- G protein-coupled receptor
- Invasion
- KISS1R
- Kisspeptin
- Metastasis