Knocking out angiotensin II in the heart

Daniela Zablocki; Junichi Sadoshima

doi:10.1007/s11906-011-0180-4

Knocking out angiotensin II in the heart

Daniela Zablocki, Junichi Sadoshima

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.

Original language	English (US)
Pages (from-to)	129-135
Number of pages	7
Journal	Current Hypertension Reports
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s11906-011-0180-4
State	Published - Apr 2011

All Science Journal Classification (ASJC) codes

Internal Medicine

Keywords

ACE
ACE2
Angiotensin II
Cardiovascular disease
Chymase
Heart
RAS
Renin
Renin-angiotensin system

Access to Document

10.1007/s11906-011-0180-4

Cite this

@article{c716fc4b227447a8bcb4e04e70a9a251,

title = "Knocking out angiotensin II in the heart",

abstract = "Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.",

keywords = "ACE, ACE2, Angiotensin II, Cardiovascular disease, Chymase, Heart, RAS, Renin, Renin-angiotensin system",

author = "Daniela Zablocki and Junichi Sadoshima",

year = "2011",

month = apr,

doi = "10.1007/s11906-011-0180-4",

language = "English (US)",

volume = "13",

pages = "129--135",

journal = "Current Hypertension Reports",

issn = "1522-6417",

publisher = "Current Medicine Group",

number = "2",

}

TY - JOUR

T1 - Knocking out angiotensin II in the heart

AU - Zablocki, Daniela

AU - Sadoshima, Junichi

PY - 2011/4

Y1 - 2011/4

N2 - Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.

AB - Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.

KW - ACE

KW - ACE2

KW - Angiotensin II

KW - Cardiovascular disease

KW - Chymase

KW - Heart

KW - RAS

KW - Renin

KW - Renin-angiotensin system

UR - http://www.scopus.com/inward/record.url?scp=79955956184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955956184&partnerID=8YFLogxK

U2 - 10.1007/s11906-011-0180-4

DO - 10.1007/s11906-011-0180-4

M3 - Review article

C2 - 21234717

AN - SCOPUS:79955956184

SN - 1522-6417

VL - 13

SP - 129

EP - 135

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 2

ER -

Knocking out angiotensin II in the heart

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this