Krill oil and xanthigen separately inhibit high fat diet induced obesity and hepatic triacylglycerol accumulation in mice

Ming Fen Lee, Ching Shu Lai, An Chin Cheng, Jain Sin Hou, Vladimir Badmaev, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Krill oil (KO) is rich in omega-3 long-chain polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid. Previous studies have shown that KO supplementation alleviated hepatic steatosis in rodents. Xanthigen (brown marine algae fucoxanthin + pomegranate seed oil) is an important source of fucoxanthin and punicic acid. Our recent work indicated that xanthigen (Xan) significantly suppressed 3T3-L1 preadipocyte differentiation and lipid accumulation. Here we investigated the effect of KO and Xan on lipid accumulation in HepG2 liver cancer cells and on high fat diet (HFD)-induced obesity in C57BL/6J mice. KO potently inhibited triacylglycerol accumulation in Hep G2 cells. Supplementation with 2.5% KO or Xan effectively reduced HFD-induced body weight gain and adipose mass increase without affecting food intake, and improved diet-induced hepatic steatosis. In summary, KO and Xan may act as novel agents for the treatment of diet-induced obesity and steatosis.

Original languageEnglish (US)
Pages (from-to)913-921
Number of pages9
JournalJournal of Functional Foods
Volume19
DOIs
StatePublished - Dec 2015

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • High-fat diet
  • Krill oil
  • Non-alcoholic fatty liver disease
  • Obesity
  • Steatosis
  • Xanthigen

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