Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor

Sung Myung; Perry T. Yin; Cheoljin Kim; Jaesung Park; Aniruddh Solanki; Pavel Ivanoff Reyes; Yicheng Lu; Kwang S. Kim; Ki Bum Lee

doi:10.1002/adma.201202961

Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor

Sung Myung, Perry T. Yin, Cheoljin Kim, Jaesung Park, Aniruddh Solanki, Pavel Ivanoff Reyes, Yicheng Lu, Kwang S. Kim, Ki Bum Lee

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.

Original language	English (US)
Pages (from-to)	6081-6087
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	45
DOIs	https://doi.org/10.1002/adma.201202961
State	Published - Nov 27 2012

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

Keywords

and enzyme detection
biosensor
graphene-based electrical detection
graphene-nanoparticle hybrid sensors

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10.1002/adma.201202961

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abstract = "A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.",

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T1 - Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor

AU - Myung, Sung

AU - Yin, Perry T.

AU - Kim, Cheoljin

AU - Park, Jaesung

AU - Solanki, Aniruddh

AU - Reyes, Pavel Ivanoff

AU - Lu, Yicheng

AU - Kim, Kwang S.

AU - Lee, Ki Bum

PY - 2012/11/27

Y1 - 2012/11/27

N2 - A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.

AB - A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.

KW - and enzyme detection

KW - biosensor

KW - graphene-based electrical detection

KW - graphene-nanoparticle hybrid sensors

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Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor

Abstract

All Science Journal Classification (ASJC) codes

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