Lack of association between iron status at birth and growth of preterm infants

Rosely Schieri, Vania Matos Fonseca, Daniel Hoffman, Nadia Maria F. Trugo, Anibal Sanchez Moura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To assess the association between iron status at birth and growth of preterm infants. Methods: Ninety-five premature babies (26 to 36 weeks of gestational age) born from July 2000 to May 2001 in a public hospital in Rio de Janeiro, Southeastern Brazil, were followed up for six months, corrected by gestational age. Iron measurements at birth were available for 82 mothers and 78 children: hemoglobin, hematocrit, mean corpuscular volume and plasma iron. All children received free doses of iron supplement (2 mg/kg/day) during the follow-up period and up to two years of age. Multivariate linear regression analyses with repeated measurements were performed to assess factors associated to linear growth. Results: Growth was more pronounced up to 40 weeks of gestational age, increasing about 1.0 cm/week and then slowing down to 0.75 cm/week. The multivariate analysis showed growth was positively associated with birth weight (0.4 cm/100 g; p≤0.001) and negatively associated with gestational age at birth (-0.5 cm/week; p≤0.001). There was no association between cord iron and mother iron measurements and growth (p>0.60 for all measures). Only two children had anemia at birth, whereas 43.9% of mothers were anemic (hemoglobin <11 g/dl). Also, there was no correlation between anemia indicators of mothers and children at birth (r<0.15; p>0.20). Conclusions: Maternal anemia was not associated with anemia in preterm infants and iron status of mothers and children at birth was not associated with short-term growth of preterm infants.

Original languageEnglish (US)
Pages (from-to)641-647
Number of pages7
JournalRevista de Saude Publica
Volume40
Issue number4
DOIs
StatePublished - Aug 1 2006

Fingerprint

Premature Infants
Iron
Parturition
Mothers
Gestational Age
Growth
Anemia
Hemoglobins
Erythrocyte Indices
Public Hospitals
Hematocrit
Birth Weight
Brazil
Linear Models
Multivariate Analysis
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Keywords

  • Anemia
  • Infant, premature, growth & development
  • Iron, blood

Cite this

Schieri, Rosely ; Fonseca, Vania Matos ; Hoffman, Daniel ; Trugo, Nadia Maria F. ; Moura, Anibal Sanchez. / Lack of association between iron status at birth and growth of preterm infants. In: Revista de Saude Publica. 2006 ; Vol. 40, No. 4. pp. 641-647.
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Lack of association between iron status at birth and growth of preterm infants. / Schieri, Rosely; Fonseca, Vania Matos; Hoffman, Daniel; Trugo, Nadia Maria F.; Moura, Anibal Sanchez.

In: Revista de Saude Publica, Vol. 40, No. 4, 01.08.2006, p. 641-647.

Research output: Contribution to journalArticle

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T1 - Lack of association between iron status at birth and growth of preterm infants

AU - Schieri, Rosely

AU - Fonseca, Vania Matos

AU - Hoffman, Daniel

AU - Trugo, Nadia Maria F.

AU - Moura, Anibal Sanchez

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N2 - Objective: To assess the association between iron status at birth and growth of preterm infants. Methods: Ninety-five premature babies (26 to 36 weeks of gestational age) born from July 2000 to May 2001 in a public hospital in Rio de Janeiro, Southeastern Brazil, were followed up for six months, corrected by gestational age. Iron measurements at birth were available for 82 mothers and 78 children: hemoglobin, hematocrit, mean corpuscular volume and plasma iron. All children received free doses of iron supplement (2 mg/kg/day) during the follow-up period and up to two years of age. Multivariate linear regression analyses with repeated measurements were performed to assess factors associated to linear growth. Results: Growth was more pronounced up to 40 weeks of gestational age, increasing about 1.0 cm/week and then slowing down to 0.75 cm/week. The multivariate analysis showed growth was positively associated with birth weight (0.4 cm/100 g; p≤0.001) and negatively associated with gestational age at birth (-0.5 cm/week; p≤0.001). There was no association between cord iron and mother iron measurements and growth (p>0.60 for all measures). Only two children had anemia at birth, whereas 43.9% of mothers were anemic (hemoglobin <11 g/dl). Also, there was no correlation between anemia indicators of mothers and children at birth (r<0.15; p>0.20). Conclusions: Maternal anemia was not associated with anemia in preterm infants and iron status of mothers and children at birth was not associated with short-term growth of preterm infants.

AB - Objective: To assess the association between iron status at birth and growth of preterm infants. Methods: Ninety-five premature babies (26 to 36 weeks of gestational age) born from July 2000 to May 2001 in a public hospital in Rio de Janeiro, Southeastern Brazil, were followed up for six months, corrected by gestational age. Iron measurements at birth were available for 82 mothers and 78 children: hemoglobin, hematocrit, mean corpuscular volume and plasma iron. All children received free doses of iron supplement (2 mg/kg/day) during the follow-up period and up to two years of age. Multivariate linear regression analyses with repeated measurements were performed to assess factors associated to linear growth. Results: Growth was more pronounced up to 40 weeks of gestational age, increasing about 1.0 cm/week and then slowing down to 0.75 cm/week. The multivariate analysis showed growth was positively associated with birth weight (0.4 cm/100 g; p≤0.001) and negatively associated with gestational age at birth (-0.5 cm/week; p≤0.001). There was no association between cord iron and mother iron measurements and growth (p>0.60 for all measures). Only two children had anemia at birth, whereas 43.9% of mothers were anemic (hemoglobin <11 g/dl). Also, there was no correlation between anemia indicators of mothers and children at birth (r<0.15; p>0.20). Conclusions: Maternal anemia was not associated with anemia in preterm infants and iron status of mothers and children at birth was not associated with short-term growth of preterm infants.

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