Lactocrine programming

Frank F. Bartol, Carol A. Bagnell

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Maternal contributions to the developmental program, beyond genetics, affect the trajectory of development and offspring phenotype. In mammals, such maternal effects do not end at birth, but continue for a period of time postnatally through signals communicated from mother to offspring in first milk (colostrum) via a lactocrine mechanism. Lactocrine programming of postnatal development is documented for reproductive tract tissues and the central nervous system, with potential for lasting effects on fecundity, cognition and behavior. Maternal lactocrine programming should be considered a component of the environmental continuum of factors connecting genotype to phenotype.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
PublisherElsevier
Pages814-820
Number of pages7
ISBN (Electronic)9780128151457
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Colostrum
  • Development
  • Developmental plasticity
  • Endometrium
  • Epigenetic
  • Female reproductive tract
  • Lactocrine
  • Lactogenesis
  • Milk
  • Neonate
  • Nursing
  • Phenome
  • Phenotype
  • Programming
  • Uterus

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