Large-scale oligonucleotide synthesis by the H-phosphonate method

Barbara L. Gaffney; Roger A. Jones

doi:10.1016/0040-4039(88)85242-0

Large-scale oligonucleotide synthesis by the H-phosphonate method

Barbara L. Gaffney, Roger A. Jones

School of Arts and Sciences, Chemistry & Chemical Biology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The H-phosphonate method is capable of giving good yields, on scales in the area of 14 μmole, with as little as 2eq of monomer. Under these conditions, however, capping was found to be necessary. Cyanoethyl H-phosphonate has been introduced for this purpose and shown to be effective.

Original language	English (US)
Pages (from-to)	2619-2622
Number of pages	4
Journal	Tetrahedron Letters
Volume	29
Issue number	22
DOIs	https://doi.org/10.1016/0040-4039(88)85242-0
State	Published - 1988

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(88)85242-0

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title = "Large-scale oligonucleotide synthesis by the H-phosphonate method",

abstract = "The H-phosphonate method is capable of giving good yields, on scales in the area of 14 μmole, with as little as 2eq of monomer. Under these conditions, however, capping was found to be necessary. Cyanoethyl H-phosphonate has been introduced for this purpose and shown to be effective.",

author = "Gaffney, {Barbara L.} and Jones, {Roger A.}",

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journal = "Tetrahedron Letters",

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AU - Gaffney, Barbara L.

AU - Jones, Roger A.

PY - 1988

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N2 - The H-phosphonate method is capable of giving good yields, on scales in the area of 14 μmole, with as little as 2eq of monomer. Under these conditions, however, capping was found to be necessary. Cyanoethyl H-phosphonate has been introduced for this purpose and shown to be effective.

AB - The H-phosphonate method is capable of giving good yields, on scales in the area of 14 μmole, with as little as 2eq of monomer. Under these conditions, however, capping was found to be necessary. Cyanoethyl H-phosphonate has been introduced for this purpose and shown to be effective.

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U2 - 10.1016/0040-4039(88)85242-0

DO - 10.1016/0040-4039(88)85242-0

M3 - Article

AN - SCOPUS:0023875343

SN - 0040-4039

VL - 29

SP - 2619

EP - 2622

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Large-scale oligonucleotide synthesis by the H-phosphonate method

Abstract

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