Laryngeal papillary squamous cell carcinoma: A population-based analysis of incidence and survival

Rahul Dutta, Qasim Husain, David Kam, Pariket M. Dubal, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objective. Papillary squamous cell carcinoma has emerged as a distinct entity from the more common keratinizing squamous cell carcinoma. The basis behind this distinction relates not only to its histologic variation but also to its overall prognosis and survival. The objective of this study was to demonstrate the incidence, demographics, and longterm survival of laryngeal papillary squamous cell carcinoma (LPSCC) and how it relates to other laryngeal malignancies using a population-based database. Study Design. Analysis of a population-based tumor registry. Methods. The United States National Cancer Institute's Surveillance, Epidemiology, and End Results registry was used to perform a retrospective analysis. Patients diagnosed with LPSCC from 1973 to 2011 were identified. Data endpoints extracted included patient demographics, incidence, and survival. Results. Three-hundred seventy cases of LPSCC were identified, corresponding to 0.5% of all laryngeal tumors. There was a 3:1 male predilection, without a significant racial preference. Most tumors identified were localized (T1) and at stage 1. The 1-year, 5-year, and 10-year disease-specific survival (DSS) for LPSCC was 97.1%, 83.1%, and 73.9%, respectively, compared with 87.9%, 64.5%, and 50.5% for other laryngeal malignancies (P values <.0001). Surgery was associated with a higher overall DSS in both LPSCC (87.4% vs 78.8%) and other laryngeal malignancies (70% vs 59.4%) when compared with other treatment modalities. Conclusion. This analysis of the largest sample of LPSCC demonstrates a better prognosis for this pathology compared with other laryngeal malignancies.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number1
StatePublished - Jul 3 2015

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


  • SEER
  • demographic
  • disease-specific survival
  • incidence
  • laryngeal cancer
  • laryngeal papillary squamous cell carcinoma.
  • papillary squamous cell carcinoma
  • population based analysis
  • relative survival
  • survival


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