Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission

David J. Barker, Jorge Miranda-Barrientos, Shiliang Zhang, David H. Root, Hui Ling Wang, Bing Liu, Erin S. Calipari, Marisela Morales

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. Here, we provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of LPO glutamate and γ-aminobutyric acid (GABA) onto single LHb neurons. In vivo, both LPO-glutamatergic and LPO-GABAergic inputs to the LHb are activated by aversive stimuli, and their predictive cues yet produce opposing behaviors when stimulated independently. These results support a model wherein the balanced response of converging LPO-glutamate and LPO-GABA are necessary for a normal response to noxious stimuli, and an imbalance in LPO→LHb glutamate or GABA results in the type of aberrant processing that may underlie mental disorders. Barker et al. show that distinct populations of lateral preoptic area glutamate and GABA neurons synapse together on single lateral habenula neurons and find that this “convergent neurotransmission” allows preoptic area neurons to exert bivalent control over single lateral habenula neurons and drive opposing motivational states.

Original languageEnglish (US)
Pages (from-to)1757-1769
Number of pages13
JournalCell Reports
Volume21
Issue number7
DOIs
StatePublished - Nov 14 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • GABA
  • aversion
  • calcium imaging
  • electron microscopy
  • glutamate
  • habenula
  • optogenetics
  • preoptic
  • reward
  • stress
  • synapse

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