Learning‐related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long‐term potentiation

Tim Otto, Howard Eichenbaum, Cynthia G. Wible, Sidney I. Wiener

Research output: Contribution to journalArticlepeer-review

243 Scopus citations

Abstract

Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high‐frequency bursts, activity 100–200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as “theta‐bursting,” are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta‐bursting occurs relatively infrequently during behavioral events less directly related to task‐relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time‐locked to behavioral events critical to learning.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalHippocampus
Volume1
Issue number2
DOIs
StatePublished - Apr 2 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Keywords

  • LTP
  • complex‐spike
  • memory
  • theta rhythm
  • theta‐bursting

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